Evron T, Caspi M, Kazelnik M, Shor-Nareznoy Y, Armoza-Eilat S, Kariv R, Manber Z, Elkon R, Sklan EH, Rosin-Arbesfeld R. A CRISPR knockout screen reveals new regulators of canonical Wnt signaling. Oncogenesis. 2021Sep 22; 10(9):63.

Siman-Tov R, Zelikson N, Caspi M, Levi Y, Perry C, Khair F, Stauber H, Sznitman J, Rosin-Arbesfeld R. Circulating Wnt Ligands Activate the Wnt Signaling Pathway in Mature Erythrocytes. Arterioscler Thromb Vasc Biol. 2021 May 5; 41(5) 243-264. 

Caspi M, Wittenstein A, Kazelnik M, Shor-Nareznoy Y, Rosin-Arbesfeld R. Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders. Adv Drug Deliv Rev. 2020 Dec 24;169:118-136.

Nadar-Ponniah PT, Taiber S, Caspi M, Koffler-Brill T, Dror AA, Siman-Tov R, Rubinstein M, Padmanabhan K, Luxenburg C, Lang RA, Avraham KB, Rosin-Arbesfeld R. Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses. Front Cell Dev Biol. 2020 Jul 15;8:615.

Kariv R, Caspi M, Fliss-Isakov N, Shorer Y, Shor Y, Rosner G, Brazowski E, Beer G, Cohen S, Rosin-Arbesfeld R. Resorting the function of the colorectal cancer gatekeeper adenomatous polyposis coli. Int J Cancer. 2020 Feb 15;146(4):1064-1074.

Margalit S, Avraham S, Shahal T, Michaeli Y, Gilat N, Magod P, Caspi M, Loewenstein S, Lahat G, Friedmann-Morvinski D, Kariv R, Rosin-Arbesfeld R, Zirkin S, Ebenstein Y. 5-Hydroxymethylcytosine as a clinical biomarker: Fluorescence-based assay for high-throughput epigenetic quantification in human tissues. Int J Cancer. 2020 Jan 1;146(1):115-122.

 

Wittenstein A, Caspi M, David Y, Shorer Y, Nadar-Ponniah PT, Rosin-Arbesfeld R. Serum starvation enhances nonsense mutation readthrough. J Mol Med (Berl). 2019 Dec;97(12):1695-1710.

Lahav-Ariel L, Caspi M, Nadar-Ponniah PT, Zelikson N, Hofmann I, Hanson KK, Franke WW, Sklan EH, Avraham KB, Rosin-Arbesfeld R. Striatin is a novel modulator of cell adhesion. FASEB J. 2019 Apr;33(4):4729-4740.

Arbel Rubinstein T, Shahmoon S, Zigmond E, Etan T, Merenbakh-Lamin K, Pasmanik-Chor M, Har-Zahav G, Barshack I, Vainer GW, Skalka N, Rosin-Arbesfeld R, Varol C, Rubinek T, Wolf I. Klotho suppresses colorectal cancer through modulation of the unfolded protein response. Oncogene. 2019 Feb;38(6):794-807.

 

Globus O, Evron T, Caspi M, Siman-Tov R, Rosin-Arbesfeld R. High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling. Sci Rep. 2017 Dec 21;7(1):17995.

 

Palevski D, Levin-Kotler LP, Kain D, Naftali-Shani N, Landa N, Ben-Mordechai T, Konfino T, Holbova R, Molotski N, Rosin-Arbesfeld R, Lang RA, Leor J. Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice. J Am Heart Assoc. 2017 Jan 6;6(1):e004387.

Skalka N, Caspi M, Lahav-Ariel L, Loh YP, Hirschberg K, Rosin-Arbesfeld R. Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. Oncogene. 2016 Dec 15;35(50):6416-6428.

Kuslansky Y, Sominsky S, Jackman A, Gamell C, Monahan BJ, Haupt Y, Rosin- Arbesfeld R, Sherman L. Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein. J Gen Virol. 2016 Dec;97(12):3313-3330.

 

Yedid N, Kalma Y, Malcov M, Amit A, Kariv R, Caspi M, Rosin-Arbesfeld R, Ben-Yosef D. The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells. BMC Cancer. 2016 Dec 23;16(1):952.

 

Caspi M, Firsow A, Rajkumar R, Skalka N, Moshkovitz I, Munitz A, Pasmanik- Chor M, Greif H, Megido D, Kariv R, Rosenberg DW, Rosin-Arbesfeld R. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents. J Mol Med (Berl). 2016 Apr;94(4):469-82. 

 

Feldman M, Hershkovitz I, Sklan EH, Kahila Bar-Gal G, Pap I, Szikossy I, Rosin-Arbesfeld R. Detection of a Tumor Suppressor Gene Variant Predisposing to Colorectal Cancer in an 18th Century Hungarian Mummy. PLoS One. 2016 Feb 10;11(2):e0147217.

 

Selvaraj P, Huang JS, Chen A, Skalka N, Rosin-Arbesfeld R, Loh YP. Neurotrophic factor-α1 modulates NGF-induced neurite outgrowth through interaction with Wnt-3a and Wnt-5a in PC12 cells and cortical neurons. Mol Cell Neurosci. 2015 Sep;68:222-33.

Franke WW, Rickelt S, Zimbelmann R, Dörflinger Y, Kuhn C, Frey N, Heid H, Rosin-Arbesfeld R. Striatins as plaque molecules of zonulae adhaerentes in simple epithelia, of tessellate junctions in stratified epithelia, of cardiac composite junctions and of various size classes of lateral adherens junctions in cultures of epithelia- and carcinoma-derived cells. Cell Tissue Res. 2015 Mar;359(3):779-97.

 

Sominsky S, Kuslansky Y, Shapiro B, Jackman A, Haupt Y, Rosin-Arbesfeld R, Sherman L. HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling. Virology. 2014 Nov;468-470:510-523.

Oz S, Kapitansky O, Ivashco-Pachima Y, Malishkevich A, Giladi E, Skalka N, Rosin-Arbesfeld R, Mittelman L, Segev O, Hirsch JA, Gozes I. The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins. Mol Psychiatry. 2014 Oct;19(10):1115-24.

Naumov I, Zilberberg A, Shapira S, Avivi D, Kazanov D, Rosin-Arbesfeld R, Arber N, Kraus S. CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APC(Min)/CD24 double knockout transgenic mice. Int J Cancer. 2014 Sep 1;135(5):1048-59.

Domke LM, Rickelt S, Dörflinger Y, Kuhn C, Winter-Simanowski S, Zimbelmann R, Rosin-Arbesfeld R, Heid H, Franke WW. The cell-cell junctions of mammalian testes: I. The adhering junctions of the seminiferous epithelium represent special differentiation structures. Cell Tissue Res. 2014 Sep;357(3):645-65.

Caspi M, Perry G, Skalka N, Meisel S, Firsow A, Amit M, Rosin-Arbesfeld R. Aldolase positively regulates of the canonical Wnt signaling pathway. Mol Cancer. 2014 Jul 4;13:164.

Dovrat S, Caspi M, Zilberberg A, Lahav L, Firsow A, Gur H, Rosin-Arbesfeld R. 14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway. Mol Oncol. 2014 Jul;8(5):894-911.

Raviv S, Bharti K, Rencus-Lazar S, Cohen-Tayar Y, Schyr R, Evantal N, Meshorer E, Zilberberg A, Idelson M, Reubinoff B, Grebe R, Rosin-Arbesfeld R, Lauderdale J, Lutty G, Arnheiter H, Ashery-Padan R. PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. PLoS Genet. 2014 May 29;10(5):e1004360.

 

Shalev M, Kandasamy J, Skalka N, Belakhov V, Rosin-Arbesfeld R, Baasov T. Development of generic immunoassay for the detection of a series of aminoglycosides with 6'-OH group for the treatment of genetic diseases in biological samples. J Pharm Biomed Anal. 2013 Mar 5;75:33-40.

 

Skalka N, Caspi M, Caspi E, Loh YP, Rosin-Arbesfeld R. Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. Oncogene. 2013 Jun 6;32(23):2836-47.

20: Raviv Z, Zilberberg A, Cohen S, Reischer-Pelech D, Horrix C, Berger MR, Rosin-Arbesfeld R, Flescher E. Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity. Br J Pharmacol. 2011 Nov;164(5):1433-44.

Hay-Koren A, Caspi M, Zilberberg A, Rosin-Arbesfeld R. The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin. Mol Biol Cell. 2011 Feb 1;22(3):399-411.

Zilberberg A, Lahav L, Rosin-Arbesfeld R. Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons. Gut. 2010 Apr;59(4):496-507.

Caspi E, Rosin-Arbesfeld R. A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling. Mol Biol Cell. 2008 Nov;19(11):4660-74.

 

Breitman M, Zilberberg A, Caspi M, Rosin-Arbesfeld R. The armadillo repeat domain of the APC tumor suppressor protein interacts with Striatin family members. Biochim Biophys Acta. 2008 Oct;1783(10):1792-802.

30: Caspi M, Zilberberg A, Eldar-Finkelman H, Rosin-Arbesfeld R. Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner. Oncogene. 2008 Jun 5;27(25):3546-55.

Rosin-Arbesfeld R, Cliffe A, Brabletz T, Bienz M. Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription. EMBO J. 2003 Mar 3;22(5):1101-13.

Thompson B, Townsley F, Rosin-Arbesfeld R, Musisi H, Bienz M. A new nuclear component of the Wnt signalling pathway. Nat Cell Biol. 2002 May;4(5):367-73.

Rosin-Arbesfeld R, Ihrke G, Bienz M. Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells. EMBO J. 2001 Nov 1;20(21):5929-39.

 

Rosin-Arbesfeld R, Townsley F, Bienz M. The APC tumour suppressor has a nuclear export function. Nature. 2000 Aug 31;406(6799):1009-12.

Rosin-Arbesfeld R, Yaniv A, Gazit A. Suboptimal splice sites of equine infectious anaemia virus control Rev responsiveness. J Gen Virol. 2000 May;81(Pt 5):1265-72.

Rosin-Arbesfeld R, Willbold D, Yaniv A, Gazit A. The Tat protein of equine infectious anemia virus (EIAV) activates cellular gene expression by read- through transcription. Gene. 1998 Sep 28;219(1-2):25-35.

Rosin-Arbesfeld R, Gazit A, Yaniv A. cDNA excision in stable retroviral cDNA transfectants is prevented by R removal. Biochem Biophys Res Commun. 1998 Sep 29;250(3):747-50.

Willbold D, Volkmann A, Metzger AU, Sticht H, Rosin-Arbesfeld R, Gazit A, Yaniv A, Frank RW, Rösch P. Structural studies of the equine infectious anemia virus trans-activator protein. Eur J Biochem. 1996 Aug 15;240(1):45-52.

Rosin-Arbesfeld R, Mashiah P, Willbold D, Rosch P, Tronick SR, Yaniv A, Gazit A. Biological activity and intracellular location of the Tat protein of equine infectious anemia virus. Gene. 1994 Dec 15;150(2):307-11.

Sticht H, Willbold D, Ejchart A, Rosin-Arbesfeld R, Yaniv A, Gazit A, Rösch P. Trifluoroethanol stabilizes a helix-turn-helix motif in equine infectious- anemia-virus trans-activator protein. Eur J Biochem. 1994 Nov 1;225(3):855-61.

Willbold D, Rosin-Arbesfeld R, Sticht H, Frank R, Rösch P. Structure of the equine infectious anemia virus Tat protein. Science. 1994 Jun 10;264(5165):1584-7.

Sticht H, Willbold D, Bayer P, Ejchart A, Herrmann F, Rosin-Arbesfeld R, Gazit A, Yaniv A, Frank R, Rösch P. Equine infectious anemia virus Tat is a predominantly helical protein. Eur J Biochem. 1993 Dec 15;218(3):973-6.

 

Rosin-Arbesfeld R, Rivlin M, Noiman S, Mashiah P, Yaniv A, Miki T, Tronick SR, Gazit A. Structural and functional characterization of rev-like transcripts of equine infectious anemia virus. J Virol. 1993 Sep;67(9):5640-6.

 

Willbold D, Krüger U, Frank R, Rosin-Arbesfeld R, Gazit A, Yaniv A, Rösch P. Sequence-specific resonance assignments of the 1H-NMR spectra of a synthetic, biologically active EIAV Tat protein. Biochemistry. 1993 Aug 24;32(33):8439-45.