Wnt and the microbiome

CRC development and patient's response to therapy are highly heterogeneous and are affected by various factors including the patient genetic background, epigenetics and the microbiome. The gut microbiome is fundamental to human health and development. Altered microbiomes have been associated with many diseases but may also serve as biomarkers or as prognostic tools. Changes in the microbiome are especially important when using antibiotic-based anti-cancer therapy strategies. Our lab is aiming at evaluateing the relationship between patients' microbiome and their genetic background, mutational spectrum, disease stage and their response to APC nonsense mutation "read-through" treatment. We are currently studying the effects of specific gut bacteria on Wnt signaling and are trying to elucidate the molecular mechanisms underlying these effects.